Na pograniczu chemii i biologii – sztuka wyboru według Profesora Krzyżosiaka Wspomnienie o Profesorze Włodzimierzu Krzyżosiaku (1949–2017)


  • Marta Olejniczak Instytut Chemii Bioorganicznej PAN, Poznań
  • Agnieszka Fiszer Instytut Chemii Bioorganicznej PAN, Poznań

Słowa kluczowe:

Włodzimierz Krzyżosiak, cancer genetics, trinucleotide repeats, polyglutamine diseases, RNA interference, microRNA


An outstanding Polish biochemist,
laureate of the Foundation for Polish Science Prize in 2007,
member of the Polish Academy of Sciences,
a head of the Department of Molecular Biomedicine
at the Institute of Bioorganic Chemistry, PAS in Poznan
Professor Wlodzimierz Krzyzosiak’s research path led from the structural chemistry of nucleic acids, through molecular genetics and cancer genetics to molecular medicine. In the last years, Professor's scientific activity focused on understanding the role of RNA in the pathogenesis of human neurological diseases caused by the expansion of repetitive sequences. He also developed new methods of experimental therapy for this group of disorders using antisense oligonucleotides and RNA interference technology. He analyzed the factors influencing the microRNA biogenesis and used this knowledge to improve RNA interference technology tools in therapeutic approaches. Overall, Professor Krzyżosiak co-authored more than 130 publications, which have been cited more than 3500 times so far.